Biochemical Effects of Formic Acid and Formaldehyde on the Activity of Selected Enzymes existing in Experimental Rats
Keywords:
Formic Acid, Formaldehyde, Enzymes, Biochemical Effects, Experimental RatsAbstract
This study aimed to evaluate the toxic effects of formic acid and formaldehyde on the biochemical enzymes in the blood using white rats. The rats were divided into seven groups: a control group, and groups treated with formic acid or formaldehyde at two different concentrations (0.5% and 1%). The effects on heart, liver, and kidney enzymes were studied, including alanine transaminase (ALT), aspartate transaminase (AS), alkaline phosphatase (ALP), creatine kinase (CPK), and blood creatinine levels, to determine the toxic effects. The results revealed that both formic acid and formaldehyde led to noticeable changes in the enzyme levels studied, indicating their harmful effects on the targeted tissues. Rats treated with a 1% concentration showed more severe effects compared to the 0.5% concentration, with a significant increase in liver and heart enzyme levels, indicating potential damage to these organs. These effects suggest that formic acid and formaldehyde cause oxidative stress and inhibit enzyme activity, leading to metabolic disturbances in the targeted organs. The study highlights the danger of chronic exposure to these chemicals, which are widely used in various industries, especially in occupational environments. The study recommends taking strict preventive measures, such as improving ventilation systems and wearing personal protective equipment to reduce exposure to these substances. Additionally, further studies are suggested to understand the molecular mechanisms behind these toxic effects.
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